Sickle cell disease is a multisystem disease of hemoglobin function. Red blood cells can change shape leading to blockage of blood vessels. Consequences include chronic anemia, jaundice, aplastic crisis, severe pain crisis, and reduce immune function. Over time, sickling crisis lead to chronic injury to virtually every organ of the body, most significantly the spleen, brain, lungs, eyes and kidneys. It is an autosommal recessive condition most common in individuals of African ancestry, but can occur in any ethnic group.