Hemolytic-uremic syndrome (HUS) is characterized by anemia and kidney failure caused by platelet problems in the kidney and other organs. Usually HUS is not-genetics and triggered by infection. Atypical HUS (aHUS) can be genetic, acquired, or idiopathic (of unknown cause). Individuals with genetic atypical HUS frequently experience relapse even after complete recovery following the presenting episode. Predisposition to aHUS ican be inherited in an autosomal recessive or autosomal dominant manner with incomplete penetrance.