Leber congenital amaurosis (LCA), a severe problem of the retina, typically showing up in the first year of life. Eight genes are known to be associated with the condition: CRX, CRB1, GUCY2D, AIPL1, RDH12, RPGRIP1, RPE65, and CEP290. Most often, LCA is passed in an autosomal recessive manner and rarely as an autosomal dominant trait.